Key Research Areas

Research Interests

• Systems Microbiology
• Molecular Biology of Infectious Diseases

Research Overview

Viruses display remarkable specificity in both the host species and the cell types that they infect. Viral genomes were characterized by high-throughput sequencing. Then viral mutation, phylogenetic tree and evolution were analyzed based on bioinformatics software. Moreover, host factors such as microRNA expression profiles were analyzed based on the next-generation sequencing (NGS) technology. After that candidate microRNAs were further analyzed for target genes by computational prediction and confirmed by in vitro studies. Understanding the interaction between virus and host cells reveal insight into the basic host components that are required for the viral life cycle and host restriction factors that limit the virus.