Evolutionary and Phylogenetic Analysis

Computational reconstruction of evolutionary relationships through molecular phylogenetics, phylogenomics, and molecular evolution analysis

Evolutionary and Phylogenetic Analysis

Overview

Evolutionary bioinformatics uses molecular sequence data to reconstruct the history of life, understand how genes evolve, and infer ancestral states. These methods are fundamental to comparative genomics, viral epidemiology, and biodiversity research.

Key Topics

  • Multiple sequence alignment methods
  • Phylogenetic tree construction (maximum likelihood, Bayesian)
  • Molecular clock models
  • Phylogenomics (genome-scale phylogenetics)
  • Positive selection detection
  • Population genetics and demographic inference

Applications

  • Viral outbreak tracing and epidemiology
  • Conservation biology and biodiversity
  • Protein function evolution
  • Co-evolution of host and pathogen